The study conducted biosynthesis of copper oxide nanoparticles using an aqueous extract of Aspergillus niger and in-vestigated their potential biomedical applications. The nanoparticles were characterized using various techniques in-cluding UV-Vis, SEM, TEM, and EDX, revealing their spherical to crystalline shape with sizes ranging from 21 nm to 48 nm. The nanoparticles demonstrated notable antimicrobial activity against Staphylococcus aureus with a zone of 8 mm and Escherichia coli recorded high synergistic activity with 20.93%, as well as antioxidant properties. Furthermore, selective cytotoxicity towards breast cancer cells was observed with an IC50 of 107.81 ug/ml and an IC50 of 250.93 ug/ml on normal cells, suggesting their potential use as an anticancer agent and for targeted drug delivery.
Muthukumarasamy, Ravindran; Nisa, Muhammad Luqman Bin; Rosli, Nur Absarina Binti; Kamaruddin, Nurul Syazwani Binti; Danish, Mohammad; Mahmad, Afzan Binti; Ibrahim, M.N. Mohamad; and Majeed, Shahnaz
"Elucidation of antibacterial, synergistic, antioxidant, and anticancer activities of green synthesized copper oxide nanoparticles against human breast cancer cells,"
Karbala International Journal of Modern Science: Vol. 9
, Article 8.
Available at: https://doi.org/10.33640/2405-609X.3305
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