Biosynthesis, characterization and antiproliferative activity of green synthesized gold nanoparticles using Lantadene A extracted from Lantana camara

Dawood Ali Salim Dawood, School of Biomedical Engineering and Health Science, Faculty of Engineering, Universiti Teknologi Malaysia and Branch of Forensic Medicine and Pathology, College of Medicine, University of Wasit, Iraq
Lee Suan Chua Ph.D, Department of Bioprocess and Polymer Engineering, School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, and Institute of Bioproduct Development, Universiti Teknologi Malaysia Follow
Tian Swee Tan Ph.D, School of Biomedical Engineering and Health Science, Faculty of Engineering, Universiti Teknologi Malaysia
Ahmed F. Alshemary Ph.D, Biotechnology Research Center, Al-Nahrain University, Baghdad, Iraq

Abstract

This study was focused on the biosynthesis of gold nanoparticles loaded with lantadene A (LA-AuNPs) from Lantana camara extract and the antiproliferative effects on prostate cancer cells (LNCaP). The synthesized LA-AuNPs had smooth surface, and nearly spherical in shape (67.94 nm) with the zeta potential (-30.11±0.83 mV). LAAuNPs showed a dose dependent cytotoxic activity with IC50, 126.82 µg/mL against LNCaP, but non-cytotoxic to normal prostate cells. The intrinsic pathway of apoptosis was caused by the increase of caspases-3/7 and -9 activity and cell cycle arrest at the G0/G1 phase. Therefore, LA-AuNPs could be a potent lead to inhibit LNCaP

Recommended Citation

Dawood, Dawood Ali Salim; Chua, Lee Suan Ph.D; Tan, Tian Swee Ph.D; and Alshemary, Ahmed F. Ph.D (2021) "Biosynthesis, characterization and antiproliferative activity of green synthesized gold nanoparticles using Lantadene A extracted from Lantana camara," Karbala International Journal of Modern Science: Vol. 7 : Iss. 4 , Article 7.
Available at: https://doi.org/10.33640/2405-609X.3158