Eutectic Formation and Cutaneous Wound Healing by Binary Allantoin- Octadecenedioic Acid System

Syed Waqar Hussain Shah, Department of Chemistry, Hazara University, Mansehra, Pakistan;Follow
Farah Ali, Department of Chemistry, Hazara University, Mansehra, Pakistan;
Iram Bibi, Department of Chemistry, Hazara University, Mansehra, Pakistan;
Kashif Ali, Department of Chemistry, Hazara University, Mansehra, Pakistan;
Neelam Pervaiz, Civil Veterinary Dispensary, Livestock and Dairy Development Department, Abbottabad, Pakistan;
Mariyum Yousaf, School of Material Science and Engineering, Hubei University, Wuchang District, Wuhan, PR China.

Abstract

Eutectic formation in allantoin-octadecenedioic acid system (AOM) has been studied. The binary phase diagram revealed the existence of eutectic at X_allantoin = 0.7. Dioic acid caused disruption of network in allantoin and induced defects, ultimately causing the reduction in crystallinity as shown by XRD and SEM analysis. The thermal stability in TGA graphs of allantoin was negligibly altered after mixture formation. Classical hydrogen bonding and alkyl interactions were predicted using software Avogadro and BIOVIA Discovery Studio. The functionalities involved in interactions taking place in the system were studied through in-depth FT-IR spectroscopy. The eutectic showed efficacy for cutaneous wound healing in oryctolagus cuniculus domesticus, hence it could be used as therapeutic for regulation and control of bioactivity.

Recommended Citation

Shah, Syed Waqar Hussain; Ali, Farah; Bibi, Iram; Ali, Kashif; Pervaiz, Neelam; and Yousaf, Mariyum (2023) "Eutectic Formation and Cutaneous Wound Healing by Binary Allantoin- Octadecenedioic Acid System," Karbala International Journal of Modern Science: Vol. 9 : Iss. 3 , Article 2.
Available at: https://doi.org/10.33640/2405-609X.3302